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Povećan je rizik od sedacije i respiratorne depresije. Poznato je da fenobarbital indukuje CYP3A4 enzim i ubrzava metabolizam diazepama u jetri, što smanjuje efekat diazepama.Lek propisuje izabrani lekar bez mišljenja lekara specijaliste određene grane medication do tri meseca u toku 12 mese
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